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ABC will launch three new dramas and four comedies in the fall, including an entirely new -- and risky -- lineup of shows on Wednesday.

New comedies starring Kelsey Grammer (Hank) and Patricia Heaton (The Middle) will lead off Wednesday, followed by laughers featuring Ed O'Neill (Modern Family) and Courteney Cox (Cougar Town) starting at 9 p.m. ET. The new drama Eastwick -- a new take on the John Updike tome The Witches of Eastwick -- will air in the 10 p.m. slot. "We really wanted to get back to family comedies," explains Stephen McPherson, ABC's entertainment president, of the 2-hour comedy block. "We needed the next generation."

The new crime drama Forgotten airs at 10 p.m. on Tuesdays behind Dancing With the Stars. Ugly Betty moves to Fridays at 9 p.m., behind Supernanny, and the new Flash Forward -- a high-concept drama about the aftermath of a 2-minute blackout -- leads off Thursdays. A reality show from Mark Burnett called Shark Tank bows on Tuesdays at 8 p.m. (though it'll get an early launch this summer after the 10th anniversary of Who Wants to Be a Millionaire). Scrubs and the sophomore show Better Off Ted will air on Tuesdays after Dancing With the Stars completes its fall run in November.

Gone is In the Motherhood, The Unusuals, According to Jim, Cupid, and Samantha Who?. "I feel really responsible for that show," concedes McPherson of the fledging sophomore laugher. "Christina Applegate is a giant TV star. It was really frustrating. It launched well but ran out of steam."

Midseason dramas include legal series The Deep End and V, a re-imagining of the miniseries about the world's encounter with aliens. As for the new comedies, Hank's about a powerful CEO-cum-family man who loses his job; The Middle is about a blue-collar family in the midwest; Cougar Town is about a divorced mom living with her teenager; and Modern Family focuses on several crazy clans.

Shark Tank gives would-be entrepreneurs a chance to turn their inventions into reality.