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Unfortunately, Isiah Washington totally fucked up the chemistry of the cast with his antics and then with his subsequent exit. But then T.R. Knight puts the nail in the coffin by going on an ego trip with his bff, Heigl. Word from production was that he became a terror. He did nothing but bitch and throw diva like fits with the crew, but most importantly, with the writers. And eventually, he pissed off the writers so much that they stopped writing for him. That's why you've seen his character more and more marginalized. They couldn't do the same with Heigl because she's the only one on the cast with an Emmy. Anyway, I can't wait until they remove the poison from the show. For the past two years, the drama behind the scenes has ruined what used to be one of the best dramas on TV.

Kind of ironic, since the most believable relationship that either Burke or George had were with each other as friends.

I could take or leave either character at this point. After Isaiahgate, people were saying that it was difficult to separate the actor's behavior from the character and I'm finding that to be the case with Heigl/Izzy. I thought her public comments about the writing with respect to her nomination was the depth of classlessness (besides IW's antics) and sadly ironic given the "solidarity" that actors were supposed to have with the writers before and during the writers' strike. The heifer can fuck off.

As for George/T.R., I always felt that he milked Isaiahgate for all he could (not that I blame him) and parlayed that into a laughable (and thankfully brief) turn as a leading man which exposed just how lacking he was in that role. With Burke out of the picture, they tried to do a similar thing with the Chief, and it didn't work nearly as well. And you have to wonder why the writers made George not only a failure (divorcee who happened to be the only intern in his class who failed the exam, when even Alex passed), but also a douche to Lexie (who has moved on to greener pastures). George can go too.

Maybe Heigl's thinking there'll be a CSI Miami-type show for her to fall back on as there was for David Caruso (of course, were that to happen, she'd have to get over her deal with writing so below par that it should invalidate award nominations).